Do you not have a dedicated subwoofer out on you integrated amp? If you are talking about connecting your preamp out to the sub, then I would say no. If your int amp has a switch to change it to preamp out, then switching it on would send all the signal to the sub and bypass the internal amp...no power for the speakers. If you leave it to the internal amp, then there would be no signal to the sub. My receiver does not have a switch, but jumpers going from the preamp out to in. By taking out the jumpers it cuts the internal amp off.