You might want to clarify your question.
If you're comparing a speaker system that has two inputs for two audio channels versus a two way speaker, which separates the audio spectrum into two different speakers one optimized for highs and the other for lows, you're comparing apples to oranges.
In any case, wiring will be easier for the former as both channels go to the same location whereby the other would have each channel going to two different locations in the each room.