IMO, I have found very, very few speakers that benefit from being set to large, but personal opinon is also a factor there. For a music only system, I would (and do) run full range, but for HT, there's no benefit unless you have main speakers that cover down to at least the 30s, which most speakers do not.
As a point of interest my main towers are 4 way. There is a 12 inch and a 10 inch sub, a 6-1/2 mid and 1 inch poly dome tweeter. Frequency response listed by the manufacturer is 25 - 21,000 hz, 94 db sens, power recommendations 20 - 275 watts. Each speaker weighs about 85 pounds. Although I doubt that you have ever heard of them they are made by Speakerlab and are the SL-7 model. I have always been extremly satisfied with their sound.