This is a difficult question to answer not knowing your space limitations.
I have been running bi-poles for over two decades and I love them.
I have never had a problem with placement in large or small areas.
I am using Def Techs for everything except my L/R which are my old ESS AMT Monitors. The theater space is 15' x 19' x 8' so I decided to go with the SuperCube I. It is all that they claim!!!
I think I'm getting frugal in my old age.
That said, I recently was in a theater demo room that was 15' x 20' x 8' with small mains and an Earthquake SuperNova 15 ($2400). The sub did not overpower the mains at all.
Personally I'ld go with the Reference and cross my mains over at 60 Hz.