Both of those factors make a huge difference. Thats why this site exists, to use science to find fact, and then allow it to be subjected to personal opinion and preference.
Part of the Audioholism is not in buying every new accessory, its in relentlessly seeking perfection. But my ear canal isn't shaped exactly the same so what I like, differs. So it is strongly encouraged to seek out and hear as much as you can! Unfortunately for me, that has involved talking with people living in FL, OK and MN!