My biggest issue with Control4, from what I have heard, is that it is a boxed solution. Less complicated always means less functionality. Bottom line. When things are simplified to a single box, like your Blu-ray player, or your cable box, then simple is a good thing. It gives you 100% control of that single product, as expected - consistently and reliably.
But, if you are talking about an adaptable system, such as your complete home audio integrated system, then products which are 'simpler' are never as dynamic in their ability to control different systems and that lack of versatility will force you to use a product, at some point, which is a compromise between what you want, and what the system demands.
This is where Crestron & AMX excel. It is not something I can go into detail on with Control4, but my limited discussions with a local Crestron/Control4 delear is that there are times when Control4 is great, and times when it is not. It really depends on you.
If I were in front of you, selling you something, then I would be pushing for Crestron, because that's what I know, backwards and forwards, and because I would source most of what you would need from them as b-stock and pass the savings on to you.
But, your real expense is not going to be the control system. It will be the equipment that runs your home. Controllable HVAC interfaces, lighting, motorized blinds, amplifiers, pre-amps, equipment racks, cooling, switching, and a lot of wiring.
But, the one thing I can say with my experience is that Crestron & AMX tend to be bulletproof once installed. You may be able to work with a dealer who can help you get some programming code so you can load and make revisions on your own, but you would need to check carefully with different installers.
I do wish you luck - I know you aren't getting a solidly defined answer from me on this.