It should be noted for the sake of proper understanding that the weaker Sub will usually set the limit for the stronger Sub. Don't think of it in terms of Power as it is the capabilities of a larger Driver in a completely different system when you look at the two Subs in question.
If you have a MiniDSP 2x4, you could put a much more finite tune on the system. Link one input to the outputs for the 2 12s, and one input to the two 16s. It will likely be a deep dive into measuring and tweaking, but I would think you could use those 12s to really augment the Mid-Bass experience and possibly add some TR to the whole set up if done properly. I do like the Nearfield idea, too.