There are a few posts you should go over that I extensively wrote covering prewiring and there is some good info on the site as well.
FIRST: You are looking at a 12 channel amplifier which will provide stereo amplification to SIX zones, not 12. Each speaker is it's own amplified channel so you actually have a total of 24 channels of amplification necessary. Perhaps a lesser expensive amp? When budget matters, I recommend the Sonance 1230 amp which is hundreds less than their 1250, but provides more power than most people ever require for listening to music. I personally use Rotel RMB-1048 amps which are 8 channel, 40WPC amps about 800 bucks (MSRP) each. I use 2 to drive 8 stereo zones and they are pretty darn loud in each zone when I crank them up.
Bottom line: PREWIRE, PREWIRE, PREWIRE! It is phenomenally cheap to prewire the heck out of your home. A nice amp, like what you have is great, but you may want to consider upgrading the volume control knobs to something that allows for remote pre-amp control.
My understanding is that volume controls throttle back the output of an amp and decrease audio quality. While a very common way of doing things, you don't get the best in audio quality, and for such a nice, high powered amp, like that, you really are getting a lot of quality, then maiming it by using volume controls.
But - price plays into it.
I recommend, that even if it isn't in the budget right now, at least wire for control keypads to go into each room with speakers. Just an extra piece of CAT-5 wiring to the control wall location.
You also should go ahead and wire EVERY room of the house up. Even those not getting speakers right away. The bathrooms, laundry areas, outdoors, garage, etc. It is easy to use up a lot more zones than you are wiring for.
CONDUIT IS YOUR FRIEND!
3/4" conduit to some locations, 1" or 2" for video locations and between floors. It opens up the possibility to add more wiring later if necessary. Especially in this time of video flux where things may change on you next year and your 'industry standard' cable now is obsolete. It is cheap, and a great way to protect yourself.
Just a aesthetic possiblity: Put the volume controller into the same box as the electrical switches. Really, no affect at all on audio quality, but you don't end up with a separate knob 4 inches away from your light switch. Conlon sells hard boxes and high voltage/low voltage separators that make this easy to install in rooms you KNOW you will have audio from the beginning.
Don't forget your home networking, phone, and cable/sat lines to be run as well! Also, if you may, possibly, put an antenna up on the room, include wiring, or retro ability, for the antenna and a rotor for it.
I ran conduit, then added XM Radio - the radio is in my basement, the antenna is in my attic. Took 30 minutes to run the wire through conduit and hook it all up. Much better than hours of trying to fish cable through a completed home.
Ask if you have more questions.