I've use the yo yo method too. Raise the cables up and down and see if it changes. It's a ground loop or a routing issue.. Sometimes placement of a new piece of gear disturbs the cable location with regards to AC cables, and ICs. The orientation of a piece sometimes causes issues with power supplies / transformers / speaker and IC cables.
Boutique coupling and decoupling caps are a prime source for noise too. They are put in backwards without regard for the trailing end of the cap wrap. It need to be pointing away from the positive, for noise rejection. They work just fine but are a nightmare in some audio racks, because of location..
Plug everything in several times, double and triple check if you're using any terminal ends (RCAs) with a twist to make them tighter. THAT is a biggie. They have to be tight. They will make noise because of it.. TIGHT is good, loose is bad..
Lifting the ground or jumper cables from piece to piece can tell you something too. A noisy LED is fun too.
SPS, laptop PS and cable wall warts can be noisy? GL suppressor will fix that or a separate dirty plug. I use 3 TripLite 2400s too. A maintainer and cleaner are never a bad idea. Unless you pay a fortune for one, that's on you, you sure don't need to. It's always the first thing I do. I protect my investment.
Vintage gear. 110vac on the button I always use a Variac and a maintainer for the Variac. New gear 120 or 220/240 on the button.
The wifes Jenson Imperials are 103 sensitivity at 16 ohms. No noise, tubes everywhere. Zero floor noise.. Routing!! is usually the trick for me unless a valve goes south.. They can drive you bonkers too.. I have a sniffer for the really tough ones, like DIY builds someone else built..
Carlson's Lab. Great designer and repairman.
I can get the schematic for one if you like.. It will find the stray noise no mater where it's at.