DVD Profiler has been fine for me. I'll be happy when they get the handheld version going though. Right now, I just export a simple list to my Ipaq.
My collection is only about 300 discs, but I find myself referring to the list a lot. Old age I guess.
Just this week I encountered a two pack with Beetlejuice and Goonies. I knew I didn't have Goonies, but wasn't sure on Beetlejuice.
I'm curious what features these other programs have that DVD Profiler doesn't? It's easy to use, has a monster database (so far, I've encountered one title that wasn't already in the db) and more search options than I'd ever find a way to use.