For me, the most important parameter is that the subwoofer has to be part of the tower speaker.
So I think this translates into aesthetic and output.
Having more than one sub also increases the total bass output, so each sub doesn't have to output 120dB from 30Hz-80Hz.
One question a lot of people ask is, should I get one big sub vs. 2 or 4 smaller subs to smooth the bass response? I would choose getting multiple smaller subs.