Horizontal lens shift is no different than vertical lens shift. If you have a projector with lens shift, you are ALWAYS using it. That is, you are shifted to the top, bottom, left, right, or center, or somewhere in between. It isn't a digital correction, but an analog one.
So, with a well designed lens system, you should always be able to use lens shift, all the way to the extents of the lens shift available, and you should not have any focus or image uniformity issues.
That said, not all lenses actually deliver. Epson is known for being good, but not perfect. Sometimes lens shift does introduce some issues. So, it is recommended to always avoid the extents of lens shift whenever possible.
BE AWARE: You can't use the maximum horizontal and vertical lens shift at the same time. Lens shift operates in a circular pattern. Why? Because lenses are round. So, if you have the projector tight to the ceiling, you can't also slide it a full screen width to the left or right.
Not sure if this link is working, but the Jack Liu calculator is one of the best I've ever seen when it comes to including lens shift capability...
projection calculator with zoom and lens shift adjustment
www.reviewtranslations.com