Maybe I'm old school l but I still use multiple remotes for my TVs, NAD Cd player, and my HK 3490. Also, my 2 Sony Blue rays.
My question is this: Who other than you actually knows how to use your system and is it easy for them to use?
I always say that when I install a control system/remote, that it isn't for the techie in the family, who gets it, but it is for their wife, their kids, their parents.
As the techie, unless you want to be the 'man in charge', then you have a responsibility to ensure that your entire family is capable of using the system easily and can't bring it to harm. This means ensuring system settings are good for them and that the buttons which can lead to problems aren't right there for them to press.
With a couple of surround systems, projector with motorized screen, multiple TVs, and more going on in my home, I needed to keep it as sane as possible for my entire family. The same type of remote is in every room with a TV. The same buttons on the remote, in the same locations make it all work.