@speakerman39 I'm not absolutely certain about this, but I suspect your Roku gadget will only understand RF signals. That Harmony remote is infrared only. I think you'd need a Harmony with a hub,
something like this Harmony Ultimate (currently on a deal of the day special, normally around $275 according to
3camels).
However, if you could live with the Harmony remote + the Roku remote for an
almost single-remote solution, then that 350 might work. The best Harmony I think is the Harmony One. There's one ending in an hour with a bid currently at $40 on eBay. You might try sniping it and see what happens, but I suspect that price will double by the end. Anyway, the One is great because of its charging cradle, its durability (owed to its hard buttons), and its touch screen soft menus handle many more activities than the 350 you found.