Interference will be nill with optical, that is it's advantage. Coaxial advantage, it fits better and is less likely to become disconnected, and shielded cables have very low interference that would not likely be noticable in most situations. Coax cables are any 75ohm cable, i.e. video cable, sub cable, and digital coax cable. Sometimes you can get a very good 6 ft. coax for well under $20, so the coax will likely be the cheapest. SQ wise, I can hear no difference as MDS already said.