Does your sub have onboard phase and crossover adjustments? I ask because at any position in your room, it is possible for your sub to work with (constructively) or against (destructively) your main speakers, and result in bass cancellation or smearing.
That's why I like the Legacy Audio subs, they let you adjust them in any position easily. I recommend playing a track with solid kick drum and sweeping phase, looking for the most solid low end. Two subs gives you an extra control point in the room and splits the load- both very good things.