Since I spend most of my time at my PC when indoors, I set up my living room audio like normal across the narrow end of the room, and simply moved my desk up to it. I have my Denon AVR, my sub amp etc. This puts my 12" mains and subs far enough behind my desk and toed-in to get that complete stereo image, with the sofas acting as partial first reflection and bass chokes of sorts that works wonders for near field.
My amps under and in front of my desk. Also considering that the DSP software from the Behringer for the subs is on my PC so I can tune on the fly from my seat if I need to. It's a bit ghetto, but I have nobody snooty that I care to impress, and my friends are all gearheads anyway so they dig it. Others, in my rather limited circle of audio friends, have set up similar systems since driving this one. The cross bar of the simple desk is bare because it's grounded, as am I when I put my feet on it, since I try to live that way as much as possible.
Where the speakers are, atop my subs, I have wedges between to aim the tweeters (DNA-360 CDs) downwards at my ear level, and are about 18" off of the front wall. This has sounded so much better than any desktop system I have ever had and I had to live with desktop speakers for about 5 years before. This sounds/measures surprisingly well. To get this level of performance for a more centrally located MLP, took a heap of room correction and a need for acoustic treatments beyond that.
Dog lays on the sofa next to me. She loves the way the bass goes thru the sofa. Soon as I turn on the subs, she is up on there for the long haul. That hadn't occurred to me until I sat on the sofa with her while the music was playing. Well, that's actually her sofa anyway, hence the comforter on it.
There is also room to put stand mount speakers in a stereo arrangement as well. These JBL S38 right at the front edge of the desk toed in, are really at home there. 8" monitors for desktop rule. Especially with the 12" subs filling in the very bottom.
The idea that desktop audio needs to be so tiny is just limiting what can often be the least problematic way to listen to music, or movies and video games for that matter. I had also considered a semi-built-in option for more of an audio console than just a simple desk. But, as it is now, I can undo 4 plugs and move the whole desk out of the way in minutes when I vacuum and dust back there.