LOTS of intagible variables so using an SPL meter and a test CD/DVD are your best friend in these applications. It is a LOT of work. Testing, repositioning, retesting, again......
Start with the subwoofer, then the center channel, then the left and right mains. It is a hair pulling test of will and committment and probably why it is rarely ever done. But, this is Audioholics and some of us are just plain anal about such things. Afterall, one is investing a great deal of money, it only seems befitting to spend just as much time properly setting it up and testing the results. The finest equipment in the world will sound no better than a Bose system if you fail to take the time up front to follow some of the recommendations of the Audioholic College and the wealth of information available to have a final product that takes full advantage of the fine equipment.
I do apologize if I hijacked your thread. I really did not want to to dig this far into room acoustics on your thread.
Enjoy.