The room is of a fairly large size and because there is no true 'front' or ideal location to pump stereo, I would likely consider running the entire room as a mono setup. Using mulitple power amps, like several Sonance 1230 or 1250 amplifiers and a couple dozen speakers and an inexpensive pre-amp for source selection/volume control.
This will provide balanced audio throughout the area with less hot spots of high audio vs. low audio. I like the idea of running multiple audio zones, but don't like external volume controls which can adversely affect audio quality and have amps running at full power a lot more often, so perhaps a 2 zone amp with both zones controllable by the remote and both zones set to the same source.
IE: Yamaha RX-V1500 - $800ish MSRP
2 Sonance 1230 amps - $2,500ish MSRP
24 speakers - $5,000ish MSRP
Maybe $2,000 to run wire and install?
I have some connections that may help in the DC area if interested.