The bigger the cabinets, the more effect these mods have... (so the Primus 250/253 and 360/362 REALLY benefit): You remove the factory stuffing. It's heat glued to the sides and bottom. It's a thin poly blanket; absolutely worthless. It does NOTHING in the majority of bandwidth the midbass drivers operate within. Use Owens Corning 703 or 705. Or use 6# or 8# mineral wool board. Use 2" on the sides of cabinet. Use 2" on back, and 4" direcly behind the drivers. Use 6" on the bottom. Place a thin cloth or thin carpet foam over the dampening to prevent fibers from coming loose and coming out the port or entering the driver vent holes. You can cut the dampening to fit tightly inside and not really need to use any glue. But I still recommend using some construction adhesive to secure the top and side pieces.

IF you want to do a little more, before you install the new dampening, apply 3-4 layers of Peel N' Seal (available at most Lowes stores), which is similar to Dynamat, but much cheaper. It is best to warm the adhesive side of the Peel N' Seal that attaches to the MDF for the best initial bond. Use a heat gun, or even a hair dryer, if that's all that is available.
Also place about 2-3" of the good dampening in the rear of the mid-range cup. Place the stock acoustic dampening back in the mid-range cup, also.
The dampening will both tighten up and produce more clarity in the mid-range, mid-bass and remove a lot of that bass hump.
The stock crossover is sufficient. You should add a good quality DSP EQ/crossover to get much more control of your sound/tone. The Behringer DCX2496 is my standard recommendation.
Also, be sure the tweeter is at ear height, or angled up to meet the ears by tilting the cabinet back a bit.
-Chris