<font color='#000000'>I can't see why not. What makes a center channel speaker suitable for the center channel is mostly the physical layout, thay are predominantly flat so they can be placed above or below TVs, screens etc.
There are some good two-ways on the market. I have a B&W two way (two driver) center speaker. Or as Rob mentions, in a D'appolito array, if the two drivers that would create lobing are fed low enough frequencies, the lobing will be minimized. However most implementations use two midrange with a center tweeter. A few are 2.5/3 way with the pair of drivers handling the bass frequencies, but these are more expensive.</font>