Depends.
In theory, no, but in practice, unless you are real careful when putting on bare, stranded wires into (or wrapping around) yer basic binding post, you can easily wind up with strays or evven a poorly tightened connection.
And, when liiking at modern HT receivers, I don't even wanna think about connecting 5, 6 or seven speakers with bare wires in that tight a spot. That's asking for trouble, particularly with my klutzy tendancies. Heck, I don't think spade lugs would fit on my Denon 2802, either.
There's no penalty in sound with any of the standard connections (bare, banana, spade and pin), assuming they are hooked up correctly and there are no shorts. Then, all bets are off.
FWIW, I use plain bananas myself for convenience sake.