I have tried both side by side. The M50s have a great deal of sweet bass, and perfect highs, while the midrange leaves something to be desired compared to the M22s. If your into clear, tight mids and highs stick to the M22s or upgrade to the M60s. If you want a somewhat more laid back speaker, the M3/M50 is the way to go. When I first listened to the two, I could hardly tell the difference, except for the bass of the M50s, but the longer I listened I began to hear the difference in these two speakers. After 3 weeks the M22s were a clear winner. But, I would suggest you call Axiom and order a pair of M60s from the FO and be done with it.