Well my concern was that I was originally gonna do structure A but didn't measure correctly so I had to move to structure B. So I was wondering how bad that would be if I used structure B. Then people started saying don't use MDF board.
If I can, I'd like to use the MDF and structure B so that I don't have to spend more money.

I'd of course add glue, screws, L-brackets, and maybe a horizontal or vertical brace(s).