As long as the screen is acoustically transparent you can have the sub behind it without hindering the sound. I'd like to see the bigger sub up front just because it will be easier to pressurize the entire room from that position than from way in the back.
I'd also probably stack or place them side by side with the smaller ones and run them as a single sub from a front position.
Part of the reason I'd run the 10"s as one sub is that they'll get a 3db bump be closer in output to whatever 15"
Then you could have a diagonal arrangement like is mentioned in one of the audioholics setup guides.
What are you using for sub EQ? That's what will be most important to all of this. If you have multiple subs, audyssey multi XT32 is really what you need. It makes a huge difference for multiple subwoofers. No matter what subs you get, without good EQ you'll never get the most out of them, unless your room is naturally awesome. Somehow I doubt it would be with the big L shape and all.