Gene might think it's significant.
I mean assuming we compare 2 amps with the same testing methodology and all - apples to apples. If one amp is -112dB SNR @ 1kHz, and one amp is -123dB SNR 20Hz-20kHz (ATI), Gene might think it's significant.
Or one amp has a XTalk of -70dB @ 1kHz/ -50dB @ 20kHz, while one amp has a XTalk of -120dB @ 1kHz/ -100dB @ 20kHz. Apples to apples. Gene might think it's significant?
But, of course, the audible significance is debatable among us.
Most of us may not think it is significant at all between -100dB SNR & -130dB SNR.