Try them both and see which one you like better. There probably isn't much, if any difference. I've used both in different set-ups and there are too many variables to give a hard and fast answer to your question. One thing, the coax may well be able to play a higher res file than the usb input if that matters to you. That said, I mainly use usb inputs because I find it more convenient in my system and I can't hear a difference.