Here is my analogy...why does it matter if the pool is 8ft or 80ft deep you still can't touch the bottom... No pun intended but dead weigh is still dead weight making hard to move..
I can move 123 pounds by myself, though I don't like moving that much by myself, especially when it is a bulky item that is not easy to grab onto. I would not move 385 pounds by myself (excluding having equipment, like a forklift, which, like most people, I do not have in my home). So for me, the difference is very significant if I ever would want to move it.
Now, for someone who is too weak to move 123 pounds, it
may not matter. But even with people who can't move that much weight by themselves, they could have a second wimpy friend and together they might be able to move 123 pounds, but there is no way the two of them are going to move 385 pounds together if they are unable to move 123 pounds separately. So it can matter for weaklings, too.
For a good subwoofer that is relatively easy to move, I strongly recommend SVS cylinder subwoofers, as they are low weight for how good they are, and the shape is easier to grab onto than most large subwoofers. Even the Ultra weighs a mere 90 pounds:
http://www.svsound.com/products-sub-cyl-pc13ultra.cfm
(The cheaper models weigh less.)
They are able to make them lightweight due to the shape. With a curve, it is stronger than a flat surface of the same material and thickness, so they are able to make the sides of the cylinder subwoofers thinner and lighter to achieve the same strength as an ordinary box, which makes them significantly lighter. The box version of the Ultra weighs 155 pounds:
http://www.svsound.com/products-sub-box-pb13ultra.cfm
So you can see that the weight savings for the cylinder is considerable. And in practice, the difference in carrying them is even greater than the mere weight difference would suggest, as the cylinder shape is easier to grab onto than a big box.
It would be even better if they made some unpowered versions, like they used to. I have a pair of these:
http://www.hometheaterhifi.com/volume_9_2/svs-cs-ultra-subwoofers-5-2002.html
They are a mere 72 pounds each, and have a shape that is relatively easy to grab onto. I have no difficulty in moving them as much as I want. I can even hold one under one arm if I wish.