I use iTunes and Apple Lossless encoding. Depending on your degree of pickiness, the sound quality of iTunes' "highest quality Variable Bitrate" is pretty much indistinguishable from the lossless, and takes considerably less disc space. I guess it depends on how many CDs you want to rip, and the capacity of your iPod. There are several other programs out there for organizing your music, but iTunes has been the easiest and most convenient for me, plus it interfaces seamlessly with iPods.