lsiberian, I recommend the URC combo offered earlier in this thread, for $85. I'm also going to ask you to consider not using the 1 touch macro.
I presently own a Harmony 520 and URC RF20. At the end of my diatribe, if you're still set on Harmony, I will consider giving it you. Maybe just shipping + $7 for me to get a sixer of some pale ale. I think the play button doesn't work so well, but I think it still might work? Worst case scenario, you can map the play button elsewhere. (yeah, the button started dying after barely more than one year. Maybe I'll take the time to take a pic of the two side by side and post it, but only if you really want to see. YMMV there). I've already used the URC for longer, no issues.
These two remotes were roughly of the same price, although the URC not only gives you RF capability, it also comes with the blaster station as well as 6 spiders. My opinions between the two, and every single thing is in favor of the URC. I can't think of a single thing I like better about the Harmony.
better buttons on the URC. Better feel. Defeatable backlight. Otherwise, adjustable timing on the backlight. 1000x easier to program. A fraction of the time to program. An even smaller fraction of the time to tweak, or add a button. More reliable operation. RF capability.
Ok, I have thought about one thing in Harmony's favor, and that is longer battery life. However, I'm sure this is a direct result from the URC firing IR + RF simultaneously. I have spent untold hours programming Harmony, and IMO, it probably ranks #1 as the most unpleasant experience I've had with AV in the few years it's been a prominent hobby of mine.
I've programmed multiple Harmonys. I had to write out a troubleshooting guide for a brain scientist of all people. When things get out of sync, laymen have such a hell of a time getting it back together.
I still have yet to see one single consumer who has used both Harmony and URC, that prefers the first. I know they exist, but I haven't read about that yet. OTOH, I've read a lot regarding the opposite.
In such case, one major concern I have is the excessive and unnecessary strikes to your components. Are you going to have your PJ set into the macro? Can you imagine her wondering why there's no pic, and using the macro function repeatedly in attempting to get it (imagine the PJ going onoffonoffonoff), while not realizing the macro is out of sync? Just being paranoid.
You can ask MDS the same thing. I remember BMX saying that the Harmony is a decent product, but that he had a recent client whose s.o. had the URC, and much preferred it to his/her Harmony.
When I programmed, I used the method recommended by MDS, in doing it "manually". Hit the desired key on URC, it immediately says ready, then hit the desired key on original. It took me less than 5 minutes per macro.
With Harmony, find your adapter plug. Open program. Login/password. Find macro. Make adjustment. Wait. Unplug remote, and test. If it doesn't work, repeat. It's been a while since, so I don't know how much better the webpages are, but before they took a while to load. Which made getting to the desired page all the more of a nuisance to me.
I suggest you set each macro on the URC, w/o one touch operation. On any given macro, simply have a page with the desired components' on/off. No need to set delays on any given key, nor "in between" commands, which if necessary will probably mean wifey is holding the remote up, carefully very still, praying "oh cmon please work!". My recommendation, IMO, is the most fool proof, and is also the easiest to troubleshoot.
I programmed one for my bro/gf/roommates. 5 min was all I needed to explain how to operate their system, and they have more components than I do. What's also convenient there is that they can tweak their usage very easily. For example, sometimes they'll be watching a sporting event, but want to play the Xbox, say at half time. I just programmed the source and receiver input into that macro. Ok, I guess you can do the same with Harmony; I guess my point is that if any function was exclusive to a single one touch macro, then you'd program as many macros as there are possibilities of usage (which also means more chances for out of sync macros).
Now, while it's particularly the CI guys here who believe in splurgin on a nice remote, for someone like you, who typically recommends saving by getting 16 gauge wire, or spending sub-1k on a PJ, or building the speakers and sub, I just have a hard time advocating spending hundreds of dollars on a remote. But, then again, when the wifey is happy, everybody is happy . . .
Harmony support is very good, and I've called them on a number of occasions. However, the thing is that URC is also known for good CS, but I can't vouch for that, as I never needed to call them.
YMMV, and these are just my opinions on the matter. Harmony is extremely popular, and I'm sure it must be for good reason. However, I'd love for any of the Harmony lovers here who have tried and/or own a URC to raise their hands.