Prepare yourself for the Bose haters...
It really depends on what you are looking for out of this. If you want something that is small and an all-in-one unit, that's one thing. If you just want a system that costs about $250, that's another.
One idea is to get an Onkyo 505 receiver for about $200 (or any receiver in that price range) and some relatively inexpensive bookshelf speakers (Circuit City had a pair of Sony bookshelves for $40 last week). Frys.com puts Polk floorstanders on sale quite often, sometimes at around $65/speaker once you include shipping.