When I clean my computer gear and pro audio gear I use my "Curtis Blaster" that uses typical CO2 cartridges in combination with a vacuum cleaner with a corner cleaning attatchment, works pretty slick, but yes, you do have to be carefull not to open the valve too far for too long, it will start spewing out liquid co2 and water that the super cold co2 condensed, if you do try one of these "blasters" make sure you have a few cartridges on hand, they can go rather quick, but pretty much put any can of compressed duster to shame.
The better alternative would be to use a combination of a static free brush and a vacuum cleaner, which would of course require the removal of the covers of the equipment, for me that's a once a year thing.
This is a good time to point out to all, that if you look through the vents on your equipment and you can visibly see a build up of dust on any components, you are already building up 20% more heat than you should, time to clean.