Toshiba sets are some of the only units out there that I would suggest an ISF calibration on, for sure. They tend to have all of the service menu settings at "0", meaning Toshiba did not even try to make the set perform it's best from the factory. That is what I have found from many reviews out there anyway.
In any case, get yourself an Avia or Avia II set up DVD. Not only will you learn something, but you will properly set up the television to it's best in the process.