I would mark the spot where the sub is sitting and move it, watching the response in REW- changing the distance in the AVR's menu won't fix problems that are caused by the sub's placement.
You can also download a Room Mode calculator, to see where the better locations would be- these are for determining modes, AKA 'standing waves' and if you took a Physics class in high school or after, you may remember wave propagation in water- the waves interact after reflecting from the sides of the tank in three ways- constructively, destructively and neutrally- sound works in the same way, except it's in three dimensions, rather than two.
You might be able to smooth the response by moving the sub a short distance, but doorways and furniture placement may not allow perfect location.