When the US military used tube amps for communication, they didn't turn off the equipment and scheduled service tasks on an annual basis unless it was needed sooner. The equipment usually worked well when the scheduled work was performed. That means the tubes were powered for about 8800 hours, continuously.
Use definitely shortens the life of tubes, but it's the ON/OFF cycles that kill the filament when the device uses solid state rectification.
I'm not saying that tube amps attract unicorns or make the Sun rise, but a great tube amp will be good enough to make the listener not think about the equipment being used. I went to the Consumer Electronics Show in Chicago for several years and one time, I wandered into the Infinity Speakers room, where they were using their top of the line IRS system. These had six 12" woofers in one cabinet and the front of the other had twenty-four EMIT tweeters and twelve EMIM midrange drivers, with an additional twelve EMIT on the rear. They were using a Conrad-Johnson Precision One power amp/Premier Two preamp, fed by a Otari 1/2" open reel tape machine. When I walked in, they were playing the sounds from a steam engine going past the microphones and solid state or tubes, it sounded very realistic and amazing! I have been close to trains when they passed enough to know that, for recorded audio, it was very close to real life.
If you want a tube amp, understand what you're getting into and don't fall for the marketing hype.