Does MDF really provide a sealed enclosure if left untreated or unpainted? The reason why I ask... I heard MDF is incredibly porous. For example, I've heard that by putting an end of a vaccuum hose on one side of a .75" MDF board and a piece of paper on the other side, the paper will stick to the board because of the vacuum. I would think this would interfere with some of the acoustical physics... causing the speaker to perform less than ideal. If this is the case, I wonder if just painting the inside (and perhaps outside too if you want to for cosmetic reasons) with a oil based primer would solve this issue.
"Incredibly porous"? Where did you hear that?
You couldn't lose pressure through MDF with a woofer if your life depended on it- whatever you heard about paper being sucked against the MDF just because of a vacuum, is plain wrong. Or, the MDF they used was crap and there are different grades of just about all lumber products. However, MDF is actually more of a paper than lumber- it's a slurry that's rolled and pressed- if you snap a 1" wide piece of it, it will actually delaminate, unlike particle board or wood.
I couldn't begin to guess the number of enclosures that I have made of MDF and never had a problem, but I also never heard of that story about pulling vacuum through it, either.
If you're concerned, coat it with paint or, if you'll use it in a wet environment, coat it with polyester resin or epoxy.
There's a saying- "if your sealed box has a small leak, you might as well make it a large one". This is such a small leak that it's inconsequential.
Why would you need oil based primer- all paints will seal it but again, it's not necessary.
If you want, I'll test this theory today- I have shop vacs and a dust collector that pulls even harder.