There is a lot to unpack here, and some of it I cannot help with.
SB Acoustics does make some good drivers. I am not certain about the Subwoofer, however.
It is not uncommon in DIY Subwoofers to get away from Plate Amps. I will be doing this with my designs currently in the works. Use something like an XLR or Speakon connector in the cabinet, then an external Amp like the Behringer NX3000 or Crown XLS1502 which contain DSP options to program controls for the Subwoofer. Amps like these can power multiple subs depending on how you wire them. Well worth looking into, IMO.
Yes and no.
There are always things to consider... but without knowing more about your design and goal, I can't predict what you may have missed, if anything at all.
Some drivers can be pushed below their Fs. Much of that depends on their Power Handling, Motor Strength, and Suspension. For example, I've seen models of the Eminence NSW6021 pushed to the low teens... Not to say that is a practical option, but theoretically doable.
I am not familiar with WinISD, but BassBox Pro will show you predicted excursion and where the driver will tap out ant different power levels.
Using DSP to program a high pass filter is common to help protect the driver down low. (Likewise, you can also program a voltage limiter in DSP to help prevent exceeding safe power handling capabilities.)
Without knowing what you are being told in the model, all I can suggest is to look at what the particle velocity may be and whether that is going to create audible noise at lower frequencies and high output. Again, my experience with BassBox is that the model will include that information and give you a warning about possible port issues.
Beyond that, make certain your ports have room to breathe... not too close to the cabinet wall where they open inside the cabinet, and not blocked by any packing material.
Bracing can be challenging... and I've looked at some intriguing ideas online. Worth researching more deeply. In short, it is recommended to brace every 10-12". While I wouldn't put a brace right up against the driver, they can definitely be near the driver. Look at flatpacks on GSG, PE, other sites and see how they look inside. Likewise checkout some build videos, especially ones using flatpacks that you can see designs of. I found this helpful to help me wrap my head around it.
Side notes:
Double up your front baffle to be 1.5" thick, with 3/4" sides.
Make certain the box itself is as airtight as possible.
Some people recommend tight bond wood glue, other like construction adhesive like Loctite PL3. (I will be using the latter.)
MDF or Baltic Birch for construction? Baltic Birch is lighter by ~1 pound per square foot, but is also more expensive. It can be easier to work with, and does not create the dust that MDF will.
Wear a respirator when cutting, routing, sanding, etc.
Dowels can be used well for bracing as opposed to window bracing and such... as I said above, you should research bracing options and plan your strategy.
Cheers!