If you want a real world example of how NOT to do it, here’s what I did: I ran two 14 gauge unshielded speaker wires from my AVR up inside the front wall, through the attic, and back down inside the rear wall. The lines are about 12 feet apart in the rear wall and connect to a pair of SVS NSD-12s.
One of the lines in the rear wall runs parallel to a power line in the same space between a pair of studs. This results in a very noticeable 60 Hz hum from that sub. I have not noticed any issues with the other sub. My hearing is not especially good, so it’s possible there’s some relatively minor funky stuff going on that I’m missing.
Based on my extremely limited data set, power lines are the natural enemy of speaker cables (at least if run in parallel near each other). I don’t know if shielded cable alone would solve the problem, but I have no intention of finding out. When I do get around to fixing it, I’m going to use shielded cable and run it well away from the power lines.
It might be interesting to experiment with a long extension cord and shielded vs unshielded cable to see how much difference it actually makes.