The first LCD page of Cable has A, B, C, LNITE (late night), PSIZE (picture size). One thing I do is try to put the function I use most on the bottom LCD button, the next most used on the second button from the bottom and so forth.
You can still use RF if you have a remote built before 1/07, you just have to use the MRF-200 or MRF-250 and not the new MRF-260 (narrow band). If the bottom of the remote says Osiris it is older; if it says MX-350 it is the narrow band version.
I've only had one minor issue with this remote. The original cable remote will scroll the guide rapidly if you press and hold the up or down arrows but the MX-350 wouldn't learn the code correctly regardless of whether I just tap and release or press and hold the arrows on the original remote. I have an old One-For-All 8811 that was taught the cable buttons years ago and I used it to teach the MX-350 the cursor up and down buttons.