-Lower the resistance the better i.e. thicker the gauge the better (to a point).
-Go with a well manufactured wire. You don't want copper corrosion creeping into the jacket. Well manufactured does not mean added bells and whistles. It means pure oxygen free copper with a decent jacket.
-Go with stranded wire instead of solid core for ease of termination and some minute benefits to sound quality.
-use the same length of cable to matching pairs of speakers (i.e. front left/right or surround left/right). Drastic differences in length can make a speaker pair not sound uniform.
-don't coil up excess speaker wire running to the amp.
Blue Jeans Cable sells good cables. Even if you don't want to buy there, the site will give you an idea what to look for:
http://www.bluejeanscable.com/