Here are my thoughts. It is not too easy to read your dimensions, but it looks like the room 18' 11" by 12' 7".
The first thing that struck me was the distance from the seating position to the screen. In your case it is 52", which is small for a design eye distance of 10 to 12 feet away.
Were you planning on moving the TV when you watch it and returning it to its corner when done?
The second issue that comes to mind is the position of the speakers relative to the TV. If you plan to relocate the TV each time, then you are fine, but if you offset the speakers from the viewing screen (or vica versa) then you will have an issue with where the sound appears and where the image appears. They won't match.
Why not go for a simple 5.1 system and move the components as follows?
You can add a sub in one of the corners if you want.
The rear speakers should ideally be 6" from the ceiling and about 2 feet above your head height when sitting. Someone recommended in-ceiling speakers and I think that is a good choice.
I would try to pull the sofa away from the wall a bit if you can, but some sound absorbent material (i.e., an Iranian Rug (Persia is long gone, you know)) hanging behind it may help some of the wall echos.
The advantage of my layout is that you can centrally locate the screen relative to the speakers and you have the long sofa available for the family and even the side sofa is still usable for viewing, too. Notice that the distance to the screen is better for viewing as well.
All the electronics can go next to the TV where you can aim a remote. The center channel should go either above or below the TV as close to the screen as possible.
The fireplace is its own entity and will not disturb your home theater when in use. And you can still enjoy just the fireplace for quiet times.