Thanks for all the responses so far. Here's a rough sketch-up of the space. Right now I'm playing with the extra room behind the couch for the second subwoofer.
The reason that I started wondering about this question is that I've read in a couple of places that if you pair two subwoofers where one is more powerful than the other, it basically has no effect, the smaller subwoofer doesn't really help improve the headroom or room response (hence the recommendation for identical subs). I was thinking that because corner loading a sub is supposed to increase room response by...6db? 3db? it might create this same situation where the corner loaded sub is doing all the work.