Does not matter if it is home/car/whatever if it is a good enclosure. It is a vented design and is intended for use with that driver. If you want to use a different one, you would need to either find one that will work with that tuning, change the tuning of that cabinet to suit another driver, or find a driver that will work in a sealed box and seal that one up.
*Edit just looked at it - looks like a bandpass design with the dual ports, so I'd say it is going to be tougher to work with. If I were doing it, I'd add a whole new front baffle for the new driver, which would plug both ports. Leave the existing amp in there and just pop some binding posts in somewhere and use an external amp.
I have an old Velodyne that died that I will eventually get around to doing something very similar to.