As is probably well known by now, I'm in the URC fan club. I have an MX-350 and the associated MRF-260 RF basestation. Together they cost a tad over $300.
The RF-20 with blaster does 90% of what the MX-350 combo can do at one third the price (it didn't exist when I bought my latest remote).
I know many people like some of the newer models (whether Harmony or URC) that have fancy graphics and icons and can control 60 pieces of AV equipment, but who needs all of that? It's like buying an expensive receiver with a zillion inputs when your HT system has 3 components. The RF-20 or MX-350 can already do more than is really necessary for most people.
To attest to the simplicity, I am now forced to watch TV with the TV speakers. The only thing worse than that of course, it to have to juggle multiple remotes. Since I had the TV commands programmed to the TV device, I just punched the TV volume commands to the Cable device so I don't have to go Main->TV->Volume->Main->Cable. Total elapsed time to make the change: 5 seconds.