Quite the contrary. I'd LOVE a set of speakers the size of Bose cubes that output as well as a decent midtower. Smaller is better from an aesthetic, and cool factor perspective.
However, in the current state of the art, multi-driver configurations handily trump single 2 1/2" drivers in sound quality.
Well, preference is a subjective thing, like you say, but that shouldn't be confused with quality. Some people prefer Hyundais to Mercedes, personally, i do not. They're not wrong in their preference, but their priorities and constraints are different. I doubt, cost being no object, many people would still pick the Hyundai though.
When it comes to listening preference, nothing matters but listening preference. However, overwhelmingly, when you pull back the curtain at the end of a blind sound test between a quality midtower and quality cube speakers, most of the world will prefer the quality of sound of the midtower. Internal speaker volume matters, surface area (for multidriver configurations) matters, separation of duties between tweeters and woofers matter. All of this is not feasible in a 3" square (or round) speaker.
Just because somethings bigger doesn't mean it sounds better though. Big speakers can and do often sound bad. Which is why i recommended the Axioms and not Technics with 15" woofers
Bookshelves can and do sound great. However, when you get down to certain size where a 2" or 3" driver is all that's possible, that small size is a serious constraint on what the speaker can produce.
Getting back on topic, in gnagel's particular case, his stands and current speakers would take up the about the same amount of floor space and height as the Axioms. Since, in his case, size doesn't appear to be the primary constraint, he would notice a big difference in extension by going with M60's/VP1xx over his current setup. IMO, they'd blend much better with his sub as well.
gnagel, this is just my opinion
In any case, good luck and do let us know how it turns out and what you think of your new set up