You certainly will. Your amp will have to overcome the pressure drop in the electrons, putting an additional strain on the power supply.
Sorry, I'm in one of those moods.
Seriously, you should be just fine. My family has run wires through basements for years with no problems at all. I really wish that I had a basement to do that in my house, as I'm looking into running wires under my carpet.
Nice job getting the speaker plates. I still need to get some. Did you get the ones with the five-way binding posts? I think that those look really slick.