Well this is something that on the surface seems simple...but it is not.
- Stands typically give weight ratings for the top surface (where the TV sits) as well as for each shelf. Obviously the bottom shelves are typically rated for more weight. The type of stands that use the little metal dowel pegs for adjustable shelves will not hold as much weight as a fixed shelf that has been doweled and glued in place. You might want to take into account your comfort factor - would you put a 45 lb component on a shelf 'rated' for 50 lbs?
- The base of the TV is much smaller than the overall width. A 52" TV on a stand 42" wide will work fine but may not look so nice. Keep in mind the depth too - ideally you want a few inches in front of and behind the TV so it won't be teetering on the edge.
- Height of the stand. They come in all sizes but the rule of thumb is you want the center to top third of the screen at eye level when seated. Some pre-built stands are just way too tall but it's personal preference.
- Doors, no doors, glass, ventilation, ease of access to the rear, wire concealment and wire routing, and on and on.
I ended up having Furniture in the Raw build me a solid Oak AV stand and it was still half the cost of some of the designs by BDI and other well known AV furniture makers. My stand is 66" wide and 22.25" tall and the 52" is about perfect for it with just a little bit of space on each side.