Hi Matt,
Welcome to the forum.
I would go with a wired system. Wireless works great for you internet but for speakers.....not so much. Remember that if you did use wireless speakers they would need a power supply to run their internal amplifier so they would still need wire just not the speaker variety.
Do you want to run all of this from your main system or do you want a separate whole house system that is just for this purpose? Many can still recievers off zone 2 & zone 3 support that share sources with your main system but power these zones with different sources.
What is your budget?