I would also kill any FI like "smooth motion", and I would also kill any NR that I'm pretty certain your TV will have. I think Vizio has low NR as default, but you can turn this completely off.
I would also use the most accurate pic mode, prolly called something like Film or Cinema. Man, it's been a while, but I saw a non-film mode TV with the lights out recently, that blue shifted crap is so irritating!
After this, you should try your hand at a calibrating bluray, like Spears Munsil or DVE. You need to choose how much light to have in the room; it can't look just right for both lights on and lights off. Or if you have user presets, make two cals, one for light, one without.
You will adjust brightness with the PLUGE low pattern, and contrast with color bars I believe. Color temperature will generally have warm as the preferred (cool being "dynamic" blue shifted, with blinding sci-fi levels of skin tones).
I have zero input on what to do with backlight.