4 ohm and 6 ohm speakers
You will be current limited by the 4 ohm speakers; the 6 ohm speakers will not be limiting. 4 ohms requires twice the current and twice the power. If you do not have a high current AVR then you will not be able to run at full volume ; maybe only 2/3rds or will get a power trip on the AVR.
And the 4 ohm, 6 ohm , 8 ohm setting on the Yamaha does not benefit you at all, its only purpose is to protect the AVR. It runs part of your power and output through an internal resistor circuit. So if you set it at 4 ohms you effectively cut your maximum power output in half.
Bottom Line: It is better to run 8 ohm speakers unless you have a specifically design high current 94 ohm support) AVR. An alternate solution is to connect Pre-out to a separate power amp to drive lower ohm, more power hungry speakers
Good Luck!
MidCow2